Published at the end of the 19th century, and employing the wide variety of illustration technologies then available, including color lithography, lithography, and photography, this work testifies to the breadth and depth of Bramwell’s medical knowledge; it illustrates, with extensive accompanying text for each image, a wide range of disorders including Addison’s disease, smallpox, cancer, hemiplegia, muscular dystrophy and the various stages of syphilis. Also included is a remarkable series of portraits of the insane, depicting patients suffering from “melancholia,” “melancholia with fear,” “melancholia with strong suicidal tendency,” “hilarious mania” and “mania.” As a contribution to the artistic depiction of disease this work is unsurpassed.