An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”
Permanent Link for Entry #13679
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Pathogen elimination by probiotic Bacillus via signaling interference.Nature, 562, 532-537, 2018.Order of authorship in the original publication: Piewngam, Zheng, Nguygen....The authors discovered a mechanism by which probiotics help maintain a healthy microbiome. They showed that Bacillus subtilis can produce a bioactive lipopeptide called Fengycin that inhibits quorum sensing of pathogens-- a vital signaling mechanism of some bacteria, which helps them regulate gene transcription. Quorum sensing is tied to and responsive to the population density of that bacteria. In this study the Bacillus fengycin eradicated Staphylococcus aureus. (Thanks to Juan Weiss for this reference and its interpretation.) Subjects: BACTERIOLOGY › BACTERIA (mostly pathogenic; sometimes indexed only to genus) › Gram-Positive Bacteria › Bacillus , MICROBIOLOGY › Microbiome, PHARMACOLOGY › PHARMACEUTICALS › Probiotics Permalink: historyofmedicineandbiology.com/id/13679 |