Znamensky, professor of stomatology in Moscow, had a very clear understanding of periodontitis, and the interaction of local and systemic factors in its etiology. He presented the first description of the histopathology of periodontal disease, and demonstrated the close association between calculus, the inflammatory response, and the migration of the epithelial attachment to produce the periodontal pocket. Very little information about Znamensky appears to be available in the western literature, his first and middle names are only recorded as initials.