An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #15902

  • 13622

Suppression of RNA recognition by toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA.

Immunity, 23, 165-175, 2005.

Karikó and Weissman discovered the nucleoside modifications that suppress the immungenicity of RNA, leading to their patents for the application of non-immunogenic, nucleoside-modified RNA (modRNA). This technology was licensed by Pfizer BioNTech and Moderna to develop their mRNA COVID-19 vaccines. Order of authorship in the original publication: Karikó, Buckstein, Ni, Weissman.

In 2023 Karikó and Weissman shared the Nobel Prize in Physiology or Medicine "for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19."

Digital facsimile from sciencedirect.com at this link.



Subjects: BIOLOGY › MOLECULAR BIOLOGY, IMMUNOLOGY › Immunization, IMMUNOLOGY › Molecular Immunology, IMMUNOLOGY › Vaccines, NOBEL PRIZES › Nobel Prize in Physiology or Medicine , VIROLOGY › VIRUSES (by Family) › Coronaviruses (Coronaviridae) › SARS CoV-2 (Cause of COVID-19), WOMEN, Publications by › Years 2000 -
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