An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16237

  • 13940

Targeted correction of a mutant HPRT gene in mouse embryonic stem cells.

Nature, 330, 576-578, 1987.

Smithies discovered, simultaneously with Mario Capecchi and Martin Evans, the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previously used, and the technique behind gene targeting and knockout mice.

In 2007 Smithies shared the Nobel Prize in Physiology or Medicine with Mario R. Capecchi and Martin J. Evans "for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells."
Order of authorship of the original publication: Doetschman, Gregg...Smithies.



Subjects: Biotechnology, NOBEL PRIZES › Nobel Prize in Physiology or Medicine
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