An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16330

  • 14023

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.

Science, 374, 1586-1593, 2021.

The authors showed how a coronavirus specific protease inhibitor designed in the lab, that could be administered by mouth to humans, achieved excellent plasma concentrations and antiviral potency. This drug, marketed as Pfizer's Paxlovid, was the first successful outpatient medicine for the treatment of COVID-19.
Order of authorship in the original publication: Owen, Allerton, Anderson.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: EPIDEMIOLOGY › Pandemics › COVID-19, PHARMACOLOGY › PHARMACEUTICALS › Antiviral Drugs, VIROLOGY › VIRUSES (by Family) › Coronaviruses (Coronaviridae) › SARS CoV-2 (Cause of COVID-19)
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