An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16062 entries, 14145 authors and 1947 subjects. Updated: December 23, 2024

Permanent Link for Entry #16457

  • 14143

Resolution of some components of adenylate cyclase necessary for catalytic activity.

J. biol. Chem. , 252, 6966-6969, 1977.

Goodman shared the 1994 Nobel Prize in Physiology or Medicine with Martin Rodbell "for their discovery of G-proteins and the role of these proteins in signal transduction in cells."

In this paper Goodman and Ross showed that a guanine nucleotide binding protein (a "G" protein) activates adenylate cyclase. They posited a system whereby a hormone receptor (adrenergic), interacts with guanine nucleotides (G proteins), and these in turn activate the enzyme adenylate cyclase, but they qualified this with a statement that "proof of function of each entity must await their purification."

Digital facsimile from PubMedCentral at this link.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Receptors, NOBEL PRIZES › Nobel Prize in Physiology or Medicine
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