An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16499

  • 14184

Cryo-electron microscopy of viruses.

Nature, 308, 34-36, 1984.

Dubochet and colleagues introduced "Dubochet's vitrification method" to vitrify water by cooling it so rapidly that it solidified to form a glass instead of crystals. Using this method, the authors published the first images of a number of different viruses, round and hexagonal.

In 2017 Dubochet shared the Nobel Prize in Chemistry with Joachim Frank and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution."

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Protein Structure, Microscopy › Cryogenic electron microscopy
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