An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16062 entries, 14145 authors and 1947 subjects. Updated: December 23, 2024

Permanent Link for Entry #16550

  • 14232

Characterization of ovine hypothalamic hypophysiotropic TSH-releasing factor.

Nature, 226, 321-325, 1970.

Working with sheep preparations, the authors determined that the molecular structure of TRF (thyroid releasing hormone), is 2-pyrrolidone-5-carboxylyl-histidyl-L-proline amide. On page 324, they showed the molecular spatial configuration of TRF. They synthesized this substance in the lab and proved that “this substance has quantitative and qualitative physicochemical and
biological characteristics which are indistinguishable from those of the natural substance isolated from the sheep.”

Guillemin shared half of the 1977 Nobel Prize in Physiology or Medicine with Andrew Schally "for their discoveries concerning the peptide hormone production of the brain." The other half of the prize was awarded to  Rosalyn Sussman Yalow "for the development of radioimmunoassays of peptide hormones."

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: ENDOCRINOLOGY, ENDOCRINOLOGY › Thyroid , NOBEL PRIZES › Nobel Prize in Physiology or Medicine
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