An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16588

  • 14267

Enhancement of antitumor immunity by CTLA-4 blockade.

Science, 271, 1734-1736, 1996.

In the early 1990s James Allison showed that CTLA-4 acts as an inhibitory molecule to restrict T-cell responses. In 1996, Allison was the first to show that antibody blockade of a T-cell inhibitory molecule (known as CTLA-4) could lead to enhanced anti-tumor immune responses and tumor rejection. Order of authorship in the original publication: Leach, Krummel, Allison.

In 2018 Allison shared the Nobel Prize in Physiology or Medicine with Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation.”  See also No. 14266.



Subjects: IMMUNOLOGY › Molecular Immunology, NOBEL PRIZES › Nobel Prize in Physiology or Medicine
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