An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

Permanent Link for Entry #16589

  • 14268

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

The EMBO Journal, 11, 341-345, 1992.

Honjo discovered the programmed cell death protein 1 (PD-1). This discovery significantly contributed to the establishment of cancer immunotherapy principle by PD-1 blockade.  Order of authorship in the original publication: Ishida, Agata, Shibahara, Honjo.

In 2018 Honjo shared the Nobel Prize in Physiology or Medicine with James P. Allison “for their discovery of cancer therapy by inhibition of negative immune regulation.”



Subjects: IMMUNOLOGY › Molecular Immunology, NOBEL PRIZES › Nobel Prize in Physiology or Medicine
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