This 44-page pamphlet was the first American manual on the administration of anesthesia. In it Morton announced that his method of producing anesthesia was obtained by the inhalation of sulphuric ether. He subsequently devoted himself to the study of surgical anesthesia and to the dissemination of information concerning it, with the expectation of enriching himself through a government grant, after the patent that he obtained together with Charles Thomas Jackson concerning the discovery proved unenforceable. Digital facsimile from the Internet Archive at this link. See No. 5660.