Jenner established the fact that a “vaccination” or inoculation with vaccinia (cowpox) lymph matter protects against smallpox. He performed his first vaccination on May 14, 1796. The above work, describing 23 successful vaccinations, announced to the world one of the greatest triumphs in the history of medicine. Jennerian vaccination soon superseded the protective inoculation of material from human cases of small-pox, which had previously been in vogue. What is probably the first mention of anaphylaxis appears on p. 13 of the pamphlet. See W.R. Lefanu, A Bio-bibliography of Edward Jenner, 1749-1823, rev. 2nd. ed., Winchester, St. Paul’s Bibliographies, 1985. Several facsimile editions have been published. As a result of the success of Jenner’s vaccine natural smallpox was eradicated. The official declaration was made by the World Health Organization on May 8, 1980. See No. 5434.2.