Sydenham has been called the “Father of English Medicine”. His reputation rests on his first-hand accounts of such conditions as the malarial fevers of his times, gout, scarlatina, measles, etc. A better edition of the above (editio altera) appeared in 1846. The original work, printed in 1685, is called editio altera; although no earlier edition is known to exist. An edition of Sydenham’s Opuscula was published in Amsterdam, 1683. See K. Dewhurst’s Dr Thomas Sydenham, his life and original writings., London, Wellcome Institute, 1966. Digital facsimile of the 1844 edition from the Internet Archive at this link; of the 1846 edition from the Hathi Trust at this link.