An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2024 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

16061 entries, 14144 authors and 1947 subjects. Updated: December 10, 2024

KOMOR, Alexis C.

1 entries
  • 11865

Programmable base editing of A-T to G-C.

Nature, 551, 464-480, 2017.

Order of authorship in the original publication: Gaudelli, Komor, Rees....Liu. 

Liu and colleagues developed an advanced CRISPR system that can edit pairings of DNA nucleotide bases Adenine and Thymine into Guanine and Cytosine. In order to achieve this they created a new enzyme in the lab to chemically convert and work on the above pairings. They called this enzyme a "base editor."  In theory this tool would enable this improved CRISPR able to target a substantial fraction of SNPs (Single-nucleotide polymorphisms) associated with human genetic diseases.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › CRISPR Gene Editing, WOMEN, Publications by › Years 2000 -