"Brenner and colleagues combined two relatively novel tools: a servo-null device for accurate measurment of capillary hydrostatic pressure... and a strain of specially selected rats with superficially located glomeruli, i.e. with overlying tubules. These two tools permitted direct measurment of the hydrostatic pressure within cannulated glomerular capillaries....

"These studies therefore radically redefined the process of glomerular filtration. Moreover, these technqiues could subsequently be applied to understand the mechanisms by which a host of mediators, disease states, and theapies modified glomerular filtration, transforming our understanding of both the process and the regulation of glomerular filtration" (Feehally et al, Landmark papers in nephrology [2013] 1.5., pp. 10-11). With J. L. Troy and T. M. Daugharty.