IVINS, Bruce Edwards
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Evidence for plasmid mediated toxin production in Bacillus anthracis.Infection and Immunity, 39, 371-376, 1983.The authors illustrated and proved that “heating V770-NPI-R containing anthrax strains, to exactly 42.5 degrees centigrade, as Pasteur and colleagues reported in GM 14211, essentially ‘cured’ these strains of their plasmid and caused a loss of detectable lethal toxin.” Near the end of their paper they stated, “In assessing Pasteur’s experimental regimen, and by utilizing modern techniques, we are able to offer a reasonable explanation for a century old molecular event which has had such a significant impact in the field of medical microbiology and it is Subjects: IMMUNOLOGY › Vaccines, VIROLOGY |