This was a paper read before the Gloucester Medical Society in 1788, but not published until 1799. Largely confirming the earlier work of Heberden on the condition, Parry stated his conclusion that disease of the coronary arteries is the responsible factor in angina pectoris (which he called “syncope anginosa”). He was the first to observe the slowing of the heart rate folowing pressure on the carotid artery.

This work "included a summary of more than two dozen experiments he [Parry] conducted on a variety of mammals. In this book he discussed the pulsatile expansion of the arteries and importance of collaterals. Parry refuted the theory that arterial pulsation was due to an intrinsic property of the vessels themselves. He attributed their motion to the force given to the blood by ventricular systole" (W. Bruce Fye, "Caleb Hillier Parry," Profiles in Cardiology, 71).

Digital facsimile from the Hathi Trust at this link.

Includes Parry’s interesting description of eight cases of exophthalmic goitre, the first of which was observed in 1786, and his notes on four cases of angina pectoris. Parry's paper, "Enlargement of the thyroid gland in connection with enlargement or palpitation of the heart," appears in vol. 2, pp. 111-129. This is classic account of exophthalmic goitre. Although Graves and Basedow have both been credited with the first description of the condition, giving their names to it, Osler called attention to the priority of Parry’s claim, and it is now sometimes referred to as “Parry’s disease”. Garrison says that Parry first noted the condition in 1786; he briefly reported it in his Elements of pathology and therapeutics, 1815. Reprinted in Med. Classics, 1940, 5, 8-30. See No. 2210.

Parry was a copious note-taker, and many of these notes are here published for the first time. His careful records of many years’ observation in practice were intended to form a large work, Elements of pathology and therapeutics, of which only the first volume appeared, in 1815; this was republished, together with the unfinished vol. 2, in 1825. In vol. 1, pp. 478-80 Parry was the first to record cases of facial hemiatrophy.

This posthumous work was seen through the press by Parry's son, the physician and writer Charles Henry Parry, who added the following supplementary volume, which is not always noticed: Introductory Essays to Collections from the unpublished Medical Writings of the late Caleb Hillier Parry, M.D.,  also published in 1825.