The first systematic publication in Great Britain on industrial disease and its prevention. For comprehensiveness, first-hand clinical experience and constructive proposals for improvements, Thackrah’s monograph is superior to that of Ramazzini. It attracted attention from both medical men and laymen at the time that it appeared, and played an important part in stimulating the factory and health legislation which mitigated some of the worst features of the Industrial Revolution. The book also includes important information on the harmful effects of child labor. The second edition (1832) was doubled in length. A reprint of the 2nd edition, with a life of the author by A. Meiklejohn, was published in 1957.