Description of venous obstruction and edema.

Classic account of aphasia. Bouillaud was the first to suggest that injuries of the frontal lobe were a cause of aphasia.

Bouillaud identified the anterior lobes as the speech center. Refuting Gall, he showed that the brain controls equilibration, station, and progression. Title of second paper varies. His earlier Traité clinique et physiologique de l’encéphalite ou inflammation du cerveau. Paris, 1825, includes some pathological and clinical studies on loss of articulate speech associated with lesions of the anterior lobes, and gives reasons for the localization of this function in the brain. See No. 4618.

Bouillaud applied Laennec's technique of auscultation to diseases of the heart. Vol. 2, page 238: “Bouillaud’s disease” – rheumatic endocarditis. Although not first to note the cardiac manifestations of acute rheumatism, Bouillaud was the first to demonstrate the frequency and importance of heart disease co-incident with acute articular rheumatism. The above work includes the first description of a case of mitral disease with articular rheumatism. Translation of the section on the pathology of endocarditis in Willius & Keys, Cardiac classics, pp. 446-55. 

"In this volume he [Bouillaud] irrevocably established the etiologic relationship between rheumatic fever and heart disease. Early reports on this relationship had been contributed by Pitcairn, Jenner, and Wells, but Bouillaud's exposition was more authoritative, comprehensive and accurate than theirs" (Willius & Dry, 125).

The merit of Bouillaud's clinical observations was somewhat vitiated by his method of cure: repeated bloodletting at short intervals.

Translated into English by James Kitchen as New researches on acute articular rheumatism in general; and especially on the law of coincidence of pericarditis and endocarditis with this disease, as well as on the efficacy of the method of treating it by repeated bloodletting at short intervals. Philadelphia: Haswell, Barrington, and Haswell, 1837.

Digital facsimile of the 1836 edition from Google Books at this link, of the 1837 edition from the Hathi Trust at this link.

Extension of Bouillaud’s work on the coincidence of heart disease and acute rheumatism. He regarded fever as the effect of endocarditis (see also No. 2749).