CARBON, John B.
1 entries
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A colony bank containing synthetic Col El hybrid plasmids representative of the entire E. coli genome.Cell, 9, 91-99, 1976.First description of a "complete" genomic library. This paper includes the Carbon-Clarke equation used for calculating the number of clones required when constructing a clone library to ensure a given probability (usually > 99% is desired) of containing any sequence, given the size of the genome and the average size of a clone. Subjects: BIOLOGY › MOLECULAR BIOLOGY › Genomics |