An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

ITAKURA, Keiichi

1 entries
  • 10964

Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin.

Science, 198, 1056-1063, 1977.

Order of authorship in the original paper: Itakura, Hirose, Crea..., Bolivar, Boyer. Synthesis of the gene for somatostatin (growth hormone-inhibiting hormone (GHIH). This was the first demonstration of a foreign gene inserted into E. coli and the first hormone genetically engineered in bacteria. The technique led to the biotechnological production of insulin by Genentech under the product name, Humulin. 

(Thanks to Juan Weiss for this reference and its interpretation).



Subjects: BIOLOGY › MOLECULAR BIOLOGY, BIOLOGY › MOLECULAR BIOLOGY › Recombinant DNA, Biotechnology