Introduction of paraffin embedding

A classic description of glomerulonephritis (“Klebs’s disease”) is on pp. 644-48.

Klebs, Professor of Pathology at Berne, Würzburg, Prague, Zurich, and Chicago, preceded Koch in investigations of the pathology of traumatic infection. He found bacteria in gunshot wounds, granulation tissue, etc., and developed his theory of a single organism, Microsporon septicum, as the cause of all pathological changes.

Klebs filtered the discharges from gunshot wounds, found the filtrate to be non-infectious, and from that reasoned that traumatic septicemia is of bacterial origin. He was the first to filter bacteria and to experiment with the filtrate.

Klebs was the first to produce experimental bovine tuberculosis (by feeding cattle with infected milk). His work confirmed the earlier researches of Villemin.

Klebs inoculated syphilis into apes and probably saw the spirochete before Schaudinn and Hoffmann.

Klebs "concluded that most cases of acute endocarditis were caused by 'monads' or by 'septic cocci' " (Bloomfield, Bibliography of internal medicine, selected diseases, 43-44). Klebs believed that all cases of endocarditis were bacterial in origin.

Klebs probably saw the typhoid bacillus before Eberth, reporting it later.

First account of Corynebacterium diphtheriae (Klebs–Loeffler bacillus), causal organism in diphtheria, discovered by Klebs.